Fractional flow reserve measurements to identify justified targets for PCI in patients with stable angina: FAME 2 and beyond

During the past decades, percutaneous coronary intervention (PCI) has become an important, widely applied therapeutic approach for the treatment of patients with symptomatic coronary artery disease and angiographically significant coronary obstructions. While the indication for PCI in the setting of acute coronary syndromes is established very well (1), there is an ongoing debate about the role of PCI in patients with ischemic heart disease and stable symptoms.